Wei Yu

Programming Targeted Immune Cell Migration Using Orthogonal Chemokine-Receptor Pairs

This study engineers orthogonal chemokine-receptor pairs to enable targeted immune cell migration and collective swarming behavior in engineered T cells.

Engineering lung-sensing T cells using synthetic receptors targeting RAGE

This paper engineers T cells with synthetic receptors that activate only in the lung, demonstrating RAGE as a lung-specific target for targeted therapies.

Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

The paper uses synthetic costimulatory domains and machine learning to identify design rules for CARs that enhance cytotoxicity and stemness.

T cell circuits that sense antigen density with an ultrasensitive threshold

This paper engineers T cells with a two-step positive feedback circuit to kill target cells based on an ultrasensitive antigen density threshold.