Rogelio Antonio Hernández-López

This study improves inducible T cell circuits by reducing basal CAR expression, enhancing discrimination between target and off-target cells.

This study uses CRISPR activation screening to identify surface ligands that regulate tumor sensitivity to NK cell killing, revealing new targets for improving NK cell-based immunotherapies.

This paper introduces scAPEX-seq, a method to map subcellular transcriptomes, and identifies CTSW as a regulator of CAR T cell function in tumor co-cultures.

Combining TCE therapy with IL-2 enhances TCE efficacy in aggressive small-cell lung cancer and melanoma models with low target antigen density through T cell clonal replacement and CD8+ effector T cell differentiation.

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

This study uses programmable microparticles to enhance CAR-T cell expansion beyond physiological limits by rewiring signaling pathways.

This paper engineers T cells with a two-step positive feedback circuit to kill target cells based on an ultrasensitive antigen density threshold.