Ludwig A. Hothorn

The paper quantifies BR receptor binding kinetics and identifies key chemical features for receptor recognition, revealing structural plasticity and functional diversity in BR signaling.

This study reclassifies plant Kelch phosphatases as PP1-like serine/threonine phosphatases involved in cell cycle regulation rather than tyrosine phosphatases in brassinosteroid signaling.

The paper identifies PP-InsP-interacting complexes in Arabidopsis, including CK2 subunits, and shows InsP6 modulates CK2 activity by blocking substrate binding.

The paper examines false positive and negative error rates in long-term carcinogenicity bioassays, focusing on their dependence on analysis methods and dose-response design.

The paper reformulates the poly-k trend test to evaluate tumor incidences in rodent carcinogenicity studies by considering multiple dose-response shapes and statistical models.

The paper proposes multiple contrast tests with multiplicity adjustment as an alternative to ANOVA F-tests to reduce false positives in biomedical studies.