Matthew S. Goldberg

Formic acid impairs α-synuclein seeding activity in human and mouse brains

This study shows formic acid treatment reduces α-synuclein seeding activity in fixed brain samples from humans and mice without compromising histopathological quality.

Alterations of PINK1-PRKN signaling in mice during normal aging

This study examines PINK1-PRKN signaling in mice during aging, showing increased gene expression and enzymatic activity in multiple tissues, with the heart showing the most pronounced activation.

Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice

This study investigates whether enhancing cathepsin D or disrupting ZKSCAN3 in the CNS can reduce α-synuclein aggregation and dopaminergic neurodegeneration, but finds no significant effect.