Jens O. Watzlawik

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

This study profiles mitochondrial respiration in IBM muscle tissue, identifying sex-specific impairments in respiration and OXPHOS complexes, along with correlations with disease severity.

This study shows that reducing mitochondrial complex I activity in mice induces AD-like transcriptomic changes, which are partially reversed by a complex I inhibitor.

This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.

This study examines PINK1-PRKN signaling in mice during aging, showing increased gene expression and enzymatic activity in multiple tissues, with the heart showing the most pronounced activation.

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

This study examines the aggregation dynamics of a 150 kDa Aβ42 oligomer using cryo-EM and other techniques, revealing unique string-like assemblies distinct from classical fibrils.

This paper develops and characterizes novel phospho-ubiquitin antibodies to detect low levels of p-S65-Ub, a marker of mitochondrial damage, in cells and tissues.