Author

Chuan Shan

Tsinghua UniversityORCID 0000-0002-5173-1335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Chenxin Wu· 1 shared Jiong YuiD· 1 shared Lei Lu· 1 shared Xiaofang Zhong· 1 shared Yuan GaoiD· 1 shared Zhuoyun Ren· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperSynthetic Biology

Chenxin Wu

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1 paper

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 16, 2026

De novo design of metalloenzymes using Metal Mer

Chuan Shan, Zhuoyun Ren, Jiong Yu…·Lei Lu

This paper introduces a computational pipeline for de novo metalloenzyme design using Metal Mer, achieving high selectivity and activity in catalytic reactions without directed evolution.

DOI 10.64898/2026.10.13.758590

protein structureprotein sequence