Synthetic BiologybioRxivPreprint
De novo design of metalloenzymes using Metal Mer
Chuan Shan, Zhuoyun Ren, Jiong Yu…·Lei Lu
This paper introduces a computational pipeline for de novo metalloenzyme design using Metal Mer, achieving high selectivity and activity in catalytic reactions without directed evolution.
DOI 10.64898/2026.10.13.758590