An increased excitation and inhibition onto CA1 pyramidal cells sets the path to Alzheimer's disease
Patrick H. Wehrle, Travis J. Rathwell, Maurice A. Petroccione…·Annalisa Scimemi
This study shows that Aβ42 accumulation increases excitatory and inhibitory synaptic transmission onto CA1 pyramidal cells and GLT-1 expression, which mediates its effects on cognition.