Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
K. Ian White, Yousuf A. Khan, Kangqiang Qiu, Ashwin Balaji, Sergio Couoh‐Cardel, Luis R. Esquivies, Richard A. Pfuetzner, Jiajie Diao, Axel T. Brünger
The paper reveals how NSF and SNAP proteins remodel SNARE complexes to enable synaptic transmission by disassembling syntaxin clusters through ATP hydrolysis.
Nature Communications · Sep 24, 2025Peer-reviewedNeuroscience