Author

Luis R. Esquivies

Howard Hughes Medical InstituteORCID 0000-0002-1750-6775Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Axel T. BrüngeriD· 4 shared K. Ian WhiteiD· 3 shared Richard A. PfuetzneriD· 3 shared Yousuf A. KhaniD· 3 shared Chuchu WangiD· 2 shared Ashwin BalajiiD· 1 shared Bharti SingaliD· 1 shared Elizabeth A. MontabanaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Axel T. BrüngerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 2, 2026

A rational design strategy and validation for protease-resistant fusion-inhibitor antiviral peptides

Kailu Yang, Chuchu Wang, Francesco Topi…·Axel T. Brünger

This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.

DOI 10.64898/2026.09.12.750390

humanproteomics

NeuroscienceNature CommunicationsPeer-reviewedSep 24, 2025

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission

K. Ian White, Yousuf A. Khan, Kangqiang Qiu…·Axel T. Brünger

The paper reveals how NSF and SNAP proteins remodel SNARE complexes to enable synaptic transmission by disassembling syntaxin clusters through ATP hydrolysis.

11 citationstop 3%

experimental assay

BiophysicsNature Structural & Molecular BiologyPeer-reviewedJul 2, 2025

SNARE disassembly requires Sec18/NSF side-loading

Yousuf A. Khan, K. Ian White, Richard A. Pfuetzner…·Axel T. Brünger

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

9 citations

yeaststructural biology

NeurosciencebioRxivPreprintOct 19, 2024

In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET

Richard G. Held, Jiahao Liang, Luis R. Esquivies…·Axel T. Brünger

This study uses cryo-electron tomography to visualize the in-situ structure and topography of AMPA receptor scaffolding complexes at molecular resolution.

9 citations

imagingexperimental assay