Developmental Immunotoxicity of Low-dose Inorganic Arsenic Reprograms Macrophages Inducing Tumor-promoting Phenotypes
Emily J. Illingworth, Sylvia S. Sanchez, Kristal A. Rychlik, André Kleensang, Gabriel A. Lopez-Cecetaite, M. Carolina Rodriguez Steube, Aakriti Mathur, Pritam Sadhukhan, Daniel A. Medina-Cleghorn, Daniel K. Nomura, Martyn T. Smith, Mohammad O. Hoque, Fenna C.M. Sillé
This study shows that low-dose inorganic arsenic exposure reprograms macrophage polarization, increasing tumor-promoting activity and altering immune responses in a sex-dependent manner.
bioRxiv · Jul 14, 2025 · PreprintImmunology