Author

André Kleensang

Johns Hopkins UniversityORCID 0000-0002-4564-7399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aakriti MathuriD· 2 shared Emily J. IllingworthiD· 2 shared Fenna C.M. SilléiD· 2 shared Kristal A. RychlikiD· 2 shared Sylvia S. SancheziD· 2 shared Alexandra MaertensiD· 1 shared Chloe M. KashiwagiiD· 1 shared Daniel A. Medina-CleghorniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

Aakriti MathurORCID

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2 papers

Recent·Most cited

Prenatal Arsenic Exposure and Gene Expression in Fetal Liver, Heart, Lung, and Placenta

Kristal A. Rychlik, Sylvia S. Sanchez, Chloe M. Kashiwagi, Jin-Shiung Liao, Aakriti Mathur, Emily J. Illingworth, André Kleensang, Alexandra Maertens, Fenna C.M. Sillé

This study examines gene expression changes in fetal liver, heart, lung, and placenta after prenatal arsenic exposure in mice, identifying immune-related pathway alterations and reduced Gbp3 expression in female placentas.

Toxicology · Feb 10, 2026Peer-reviewedPharmacology & Toxicology

Developmental Immunotoxicity of Low-dose Inorganic Arsenic Reprograms Macrophages Inducing Tumor-promoting Phenotypes

Emily J. Illingworth, Sylvia S. Sanchez, Kristal A. Rychlik, André Kleensang, Gabriel A. Lopez-Cecetaite, M. Carolina Rodriguez Steube, Aakriti Mathur, Pritam Sadhukhan, Daniel A. Medina-Cleghorn, Daniel K. Nomura, Martyn T. Smith, Mohammad O. Hoque, Fenna C.M. Sillé

This study shows that low-dose inorganic arsenic exposure reprograms macrophage polarization, increasing tumor-promoting activity and altering immune responses in a sex-dependent manner.

bioRxiv · Jul 14, 2025 · PreprintImmunology