Kirsty L. Spalding

Effect of Alcohol and Cocaine Abuse on Neuronal and Non-Neuronal Cell Turnover in the Adult Human Hippocampus

The paper assesses neuronal and non-neuronal cell turnover in the hippocampus of individuals with alcohol or cocaine abuse compared to healthy controls, finding no significant difference in turnover rates between groups.

A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elements

The paper constructs a human DNA methylation atlas using whole-genome bisulfite sequencing of 39 cell types, revealing cell type-specific methylation patterns and regulatory elements.

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

The paper develops a method to determine the tissue origins of circulating cell-free DNA using a methylation atlas and validates it in healthy and disease states.