Zuolin Cheng

This study identifies microglial subpopulations and shows their origin and transitions through transcriptomic and epigenomic analysis.

The paper maps 5mC and 5hmC modifications in mouse cortical cell types using Nanopore sequencing and RNA sequencing, revealing astrocytes as a major source of 5hmC and providing a resource for methylome analysis.

The paper introduces CMC, a model that efficiently learns multifactorial effects in biological data and outperforms existing methods in several applications.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

ABDS provides tools for analyzing biologically diverse samples by addressing missing value imputation, signature gene detection, and expression pattern visualization.

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

This study uses scRNA-seq to analyze microglia and myeloid cells across brain regions and developmental stages, revealing heterogeneity in postnatal microglia and their roles in disease.