Qingyun Li

This study shows that deleting BTK in B cells reduces EAE severity by impairing autoreactive B cell functions, supporting BTK as a therapeutic target in MS.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

The paper identifies microglial states and activation genes in aging and parabiosis, revealing region-specific responses and vulnerabilities in the brain.

This study identifies microglial subpopulations and shows their origin and transitions through transcriptomic and epigenomic analysis.

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

This study uses scRNA-seq to analyze microglia and myeloid cells across brain regions and developmental stages, revealing heterogeneity in postnatal microglia and their roles in disease.