Alexander P. Clark

SP1 tethers NR2F2 to drive atrial cardiomyocyte identity

The paper identifies SP1 as a transcription factor necessary for human atrial cardiomyocyte identity, showing it interacts with NR2F2 to drive gene regulation.

Paired single-cell imaging of calcium and expression to map niches of identity and function

This paper introduces CARBONITE, a method that links calcium dynamics with molecular markers in single cardiomyocytes, revealing functional and identity heterogeneity.

Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease

This study shows that reduced TBX5 dosage disrupts atrial cardiomyocyte identity, leading to cellular and molecular changes associated with atrial diseases.

MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis

This study identifies MEF2C-dependent gene regulatory networks in specific heart segments and shows their role in heart tube morphogenesis using multi-omics data and deep learning.

Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

This paper develops a computational model to identify and correct artefacts in voltage-clamp experiments, improving the accuracy of ion channel recordings.