Brian L. Black

Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes

This study identifies a shared cellular origin for supraclavicular brown adipocytes and beige adipocytes in inguinal white adipose tissue through lineage tracing.

MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis

This study identifies MEF2C-dependent gene regulatory networks in specific heart segments and shows their role in heart tube morphogenesis using multi-omics data and deep learning.

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats

This study shows Zfp106 binds to G-quadruplex RNAs formed by GGGGCC repeats, inhibiting RAN translation and RNA foci formation in C9orf72-related diseases.

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

This paper identifies sequential phases of ETV2-dependent gene expression that drive hematoendothelial fate commitment from mesoderm progenitors.

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors

The paper identifies a Mesp1-dependent developmental breakpoint in cardiac precursor cell specification using single-cell transcriptomics and chromatin accessibility analysis in mouse embryos.

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo, making it a promising target for heart disease.

Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis

The paper uses single-cell epigenomics and machine learning to model cell-cell communication networks in cardiac development and identify dysregulation in TBX1 deletion.

Control of ribosomal protein synthesis by Microprocessor complex

The paper shows the Microprocessor complex regulates ribosomal protein synthesis by binding TOP motifs and promoting transcription elongation, linking ribosome biogenesis to cell growth.

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

Estimating the rate of cell type degeneration from epigenetic sequencing of cell-free DNA

This paper introduces CelFiE, a method to estimate cell type contributions to cfDNA, showing it can detect rare cell types and find increased skeletal muscle cfDNA in ALS patients.

Genomic Analysis of a Transcriptional Networks Directing Progression of Cell States During MGE development.

The paper identifies regulatory elements and transcription factors involved in GABAergic and cholinergic neuron fate maturation during MGE development.