Ralph A. Nixon

This study investigates the role of the autophagy-lysosomal pathway in Huntington's disease, finding that autophagic flux declines due to substrate clearance deficits in later stages.

This study shows that overexpressing APPL1 in neurons causes AD-like endosomal and synaptic dysfunction, cholinergic neurodegeneration, and memory deficits in mice.

This study shows that mTOR inhibition in HD model mice improves autophagy and reduces mutant huntingtin accumulation.

This study identifies that phosphorylated APP βCTF inhibits v-ATPase in Down Syndrome and Alzheimer's models, leading to lysosomal dysfunction.

The paper curates a list of 838 high-confidence components of the autophagy-lysosome pathway as part of a comprehensive effort to define the human proteostasis network.

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.