Author

Nicolas Lounsbury

GenentechORCID 0000-0002-5214-3404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Iain D. C. FraseriD· 2 shared William John ThriftiD· 2 shared Ajay Suresh AkhadeiD· 1 shared Andrew WallaceiD· 1 shared Bhaskar DuttaiD· 1 shared Carolyn J. HutcheoniD· 1 shared Clare Elizabeth BryantiD· 1 shared Clifford RostomilyiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioinformatics

Iain D. C. FraserORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologyCell SystemsPeer-reviewedAug 13, 2026

Predicting specificity of TCR-pMHC interactions using machine learning and biophysical models

Martin Culka, Nicolas Lounsbury, William John Thrift…·Mohammed AlQuraishi

This study evaluates ML and biophysical models for predicting TCR-pMHC specificity, showing ML struggles with novel peptides while biophysical methods excel but underperform on known ones, leading to a hybrid model with improved performance.

8 citationstop 2%

humanproteomics

ImmunologybioRxivPreprintOct 14, 2024

Pep2Vec: An Interpretable Model for Peptide-MHC Presentation Prediction and Contaminant Identification in Ligandome Datasets

William John Thrift, Quade Broadwell, Jason F. Perera…·Suchit Jhunjhunwala

1 citation

proteomicsdeep learning

BioinformaticsCell SystemsPeer-reviewedMar 24, 2021

TRIAGE: A web-based iterative analysis platform integrating pathway and network approaches optimizes hit selection from high- throughput assays.

Samuel Katz, Jian Song, Kyle P. Webb…·Iain D. C. Fraser

TRIAGE integrates pathway and network methods to optimize gene hit selection from high-throughput assays, improving consistency across genome-wide studies.

15 citations

statistical modelbenchmarking

Systems BiologyScience SignalingPeer-reviewedDec 8, 2020

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity

Leah M. Rommereim, Ajay Suresh Akhade, Bhaskar Dutta…·Naeha Subramanian

A small increase in NOD1 expression leads to cancer-promoting changes in cell state by promoting persistent inflammation and oncogene expression.

10 citations

humanproteomics