Author

William John Thrift

GenentechORCID 0009-0004-5022-2119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Nicolas LounsburyiD· 2 shared Andrew WallaceiD· 1 shared Darya Yu. OrlovaiD· 1 shared Gergő NikolényiiD· 1 shared Jason F. Perera· 1 shared Jieming CheniD· 1 shared Kiran MukhyalaiD· 1 shared Martin CulkaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Nicolas LounsburyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ImmunologyCell SystemsPeer-reviewedAug 13, 2026

Predicting specificity of TCR-pMHC interactions using machine learning and biophysical models

Martin Culka, Nicolas Lounsbury, William John Thrift…·Mohammed AlQuraishi

This study evaluates ML and biophysical models for predicting TCR-pMHC specificity, showing ML struggles with novel peptides while biophysical methods excel but underperform on known ones, leading to a hybrid model with improved performance.

8 citationstop 2%

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 14, 2024

Pep2Vec: An Interpretable Model for Peptide-MHC Presentation Prediction and Contaminant Identification in Ligandome Datasets

William John Thrift, Quade Broadwell, Jason F. Perera…·Suchit Jhunjhunwala

1 citation

proteomicsdeep learning

𝕏 PostBluesky