Author

Changyou Zhan

Shanghai Medical College of Fudan UniversityORCID 0000-0002-5215-2829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:multiome· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

Guanghui LiiD· 2 shared Yinyu Ma· 2 shared Zhiwei Guo· 2 shared Zui ZhangiD· 2 shared Anqi WeiiD· 1 shared Bin Wang· 1 shared Caijun SuniD· 1 shared Dexuan LeiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Guanghui LiORCID

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Author profile →

3 papers

Recent·Most cited

Pulmonary mRNA-LNP Vaccines for Rapid and Durable Protection Against Bacterial Infection

Anqi Wei, Yu Miao, Zhou Yuan, Guanghui Li, Dexuan Lei, Yinyu Ma, Zhiwei Guo, Y W Sun, Tianhao Ding, Kaisong Tian, Qin He, Zui Zhang, Lianfeng Fan, Changyou Zhan, Xiaoli Wei

This paper develops a pulmonary mRNA-LNP vaccine that provides rapid and durable protection against bacterial lung infections by integrating innate and adaptive immune responses.

Nature Communications · Jul 8, 2026Peer-reviewedBioengineering

Hydroxy polyethylene glycol: a solution to evade human pre-existing anti-PEG antibodies for efficient delivery

Tianhao Ding, Jiaru Fu, Min Yang, Zui Zhang, Yinyu Ma, Ercan Wu, Zhiwei Guo, Shiqi Lin, Songli Wang, Xiaohua Liu, Weiping Wang, Bin Wang, Guanghui Li, Changyou Zhan

This study shows that hydroxy PEG (OH-PEG) reduces binding to pre-existing anti-PEG antibodies, improving stability and reducing immunogenicity of PEGylated nanomedicines.

ACS Nano · Jun 9, 2026Peer-reviewedPharmacology & Toxicology

Deep Generative Optimization of mRNA Codon Sequences for Enhanced mRNA Translation and Therapeutic Efficacy

Yupeng Li, Fan Wang, Jiaqi Yang, Zirong Han, Lin‐Feng Chen, Wenbing Jiang, Hao Yu Zhou, Tong Li, Zehua Tang, Jianxiang Deng, Xin Yi He, Gao‐Feng Zha, Zhaoyu Hu, Yong Hu, Linping Wu, , Zhi Xie

RiboDecode generates optimized mRNA codon sequences using deep learning, improving protein expression and therapeutic efficacy in vitro and in vivo.

Nature Communications · Nov 12, 2025Peer-reviewedBioinformatics