Tong Li

RiboDecode generates optimized mRNA codon sequences using deep learning, improving protein expression and therapeutic efficacy in vitro and in vivo.

The paper identifies and analyzes nonreference sequences in human genomes using long-read sequencing and graph-based pangenome methods, revealing their functional, evolutionary, and phenotypic significance.

The paper benchmarks structural variation detection using long reads through a simulated model, finding that combining multiple callers improves recall and precision.

The paper performs long-read sequencing in 405 Chinese individuals to discover and characterize structural variants, finding novel SVs and their associations with phenotypes and diseases.