Author

Hervé Leh

Centre National de la Recherche ScientifiqueORCID 0000-0002-5221-7717Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Hoda JaffaliD· 2 shared Nicolas Delhaye· 2 shared Stéphanie Bury‐MonéiD· 2 shared Sylvie LautruiD· 2 shared François R. Pelé· 1 shared Jean‐Luc PernodetiD· 1 shared Thomas B. GregoryiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

Hoda JaffalORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Effect of gene cluster relocation to the central chromosomal compartment on its expression in Streptomyces

Nicolas Delhaye, Hoda Jaffal, Thomas B. Gregory, Hervé Leh, Jean‐Luc Pernodet, Sylvie Lautru, Stéphanie Bury‐Moné

This study relocates a gene cluster to the central chromosomal compartment in Streptomyces, enhancing its transcription and antibiotic production without altering chromosome compaction.

bioRxiv · Mar 4, 2026 · PreprintMicrobiology

A new-engineered integrative tool to target the terminal compartment of the Streptomyces chromosome

Nicolas Delhaye, François R. Pelé, Hoda Jaffal, Sylvie Lautru, Hervé Leh, Stéphanie Bury‐Moné

This paper introduces a new integrative tool, Samy, for targeting the terminal compartment of Streptomyces chromosomes, expanding genetic engineering capabilities.

Applied Microbiology and Biotechnology · Feb 21, 2026Peer-reviewedBioengineering