Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Hannah Ochner, Buse Isbilir, Sonja Blasche, David Scheidweiler, Yuexuan Zhang, Zhexin Wang, Tom S. Smith, Catarina de Matos Ferraz Franco, R. E. Bradley, Kiran Raosaheb Patil, Tanmay A. M. Bharat
This paper combines cryo-EM and FIB-SIMS to map sub-cellular chemical distributions in bacteria, revealing pollutant storage in phase-separated aggregates.
bioRxiv · Aug 29, 2025 · PreprintMolecular Biology