Author

David Scheidweiler

University of CambridgeORCID 0000-0002-9507-455XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Kiran Raosaheb PatiliD· 4 shared Sonja BlascheiD· 3 shared Hannah OchneriD· 2 shared R. E. BradleyiD· 2 shared Simone MozzachiodiiD· 2 shared Stephan KamradiD· 2 shared Tanmay A. M. BharatiD· 2 shared Alexander J. WestermanniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

Kiran Raosaheb PatilORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Laboratory evolution enhances resilience of a symbiont yeast and its honeybee host against agrochemical exposure

Simone Mozzachiodi, Flavia Di Cesare, Stephan Kamrad, Xiaoteng Jiang, David Scheidweiler, Jack Rogan, Sandip Kumar Patel, Anna E. Lindell, Luisa Faria, David Baracchi, Kiran Raosaheb Patil

The paper uses laboratory evolution to identify yeast resistance mechanisms against agrochemicals and shows how evolved yeast can protect honeybee hosts.

bioRxiv · Jul 10, 2026 · PreprintMicrobiology

Oxygen gradients reshape cross-feeding through emergent spatial organization of gut commensal bacteria

David Scheidweiler, Elise Bornet, Hannah Ochner, Sonja Blasche, Stanislas Thiriet-Rupert, Louis Dorison, Christophe Beloin, Yohan Davit, Samy Gobaa, Tanmay A. M. Bharat, Alexander J. Westermann, Kiran Raosaheb Patil, Jean‐Marc Ghigo

The paper shows how oxygen gradients in the gut reshape cross-feeding between Bacteroides thetaiotaomicron and Escherichia coli through spatial organization and metabolic feedback.

bioRxiv · May 2, 2026 · PreprintMicrobiology

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Hannah Ochner, Buse Isbilir, Sonja Blasche, David Scheidweiler, Yuexuan Zhang, Zhexin Wang, Tom S. Smith, Catarina de Matos Ferraz Franco, R. E. Bradley, Kiran Raosaheb Patil, Tanmay A. M. Bharat

This paper combines cryo-EM and FIB-SIMS to map sub-cellular chemical distributions in bacteria, revealing pollutant storage in phase-separated aggregates.

bioRxiv · Aug 29, 2025 · PreprintMolecular Biology

Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism

Stephan Kamrad, Simone Mozzachiodi, Sonja Blasche, Simran Kaur Aulakh, David Scheidweiler, Arianna Basile, Rui Guan, Rob Bradley, Naomi Iris van den Berg, Michael Mülleder, Markus Ralser, Kiran Raosaheb Patil

This study examines how bacterial proteomes and metabolomes change in response to interspecies interactions in gut microbiota co-cultures, revealing extensive molecular reorganization and emergent metabolic pathways.

bioRxiv · May 14, 2025 · PreprintMicrobiology