Author

Srinivasan Sakthivel

National University of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ambrin FatimaiD· 1 shared Auriel Theodora Jacobea Lim· 1 shared Boaz P. LeviiD· 1 shared Canan DoğanlıiD· 1 shared Cecilie Keller· 1 shared Dean NižetićiD· 1 shared Hans EibergiD· 1 shared Henrik NielseniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Ambrin FatimaORCID

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2 papers

Recent·Most cited

Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networks

Michael Lattke, Wee Leng Tan, Salil Kalarikkal Sukumaran, Kagistia Hana Utami, Marcos Sintes, Srinivasan Sakthivel, Jonathan Tan, Auriel Theodora Jacobea Lim, Vibhavari Aysha Bansal, Katerina Rekopoulou, Nik Matthews, Ivan Alić, Željka Krsnik, Dean Nižetić, Boaz P. Levi, Vincenzo De Paola

The paper constructs a single-cell atlas of fetal Down syndrome cortex, identifying chromosome 21 transcription factors that regulate intellectual disability gene networks and showing their normalization can restore molecular signatures.

bioRxiv · Dec 30, 2025 · PreprintNeuroscience

RRP7A links primary microcephaly to radial glial cells and dysfunction of ribosomal biogenesis, neurogenesis and ciliary resorption

Muhammad Farooq, Louise Lindbæk, Nicolai Krogh, Canan Doğanlı, Cecilie Keller, Maren Mönnich, Srinivasan Sakthivel, Yuan Mang, Ambrin Fatima, Vivi Søgaard Andersen, Muhammad Sajid Hussain, Hans Eiberg, Lars Hestbjerg Hansen, Klaus Wilbrandt Kjaer, Jay Gopalakrishnan, , Lars Allan Larsen

This study identifies a mutation in RRP7A linked to primary microcephaly, showing its role in neurogenesis, ribosomal biogenesis, and ciliary resorption in neural stem cells.

bioRxiv · Oct 10, 2019 · PreprintNeuroscience