Lotte Bang Pedersen

Primary cilia coordinate c-KIT signaling induced proliferation in alpha cells

The paper identifies primary cilia as a signaling platform for c-KIT in pancreatic alpha cells, showing that c-KIT signaling via SCF promotes proliferation and may contribute to hyperglucagonemia in obesity and diabetes.

Analysis of motor-based transport in primary cilia by dynamic mode decomposition of live-cell imaging data

The paper uses dynamic mode decomposition to analyze live-cell imaging data and investigates KIF13B's role in ciliary transport, finding it does not affect IFT velocity or frequency in a deletion mutant.

INPP5E interactome reveals novel connections to growth factor signaling

This study identifies INPP5E interactors involved in growth factor signaling, revealing its role in regulating ciliary pathways in fibroblasts.

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development

The paper identifies TAK1's role in heart development through genetic analysis and shows its activation at the primary cilium via TGFB/BMP signaling.

NBCn1 interacts with DYNLL1 and regulates ciliary length and SUFU localization to control Sonic hedgehog signaling

This paper identifies NBCn1 as a ciliary membrane component that regulates ciliary length and Sonic hedgehog signaling through interactions with DYNLL1 and SUFU.

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

This study shows KIF13B regulates ciliary protein content by promoting endocytic retrieval and suppressing large EV release from cilia, with distinct effects during ciliation stages.

CAKUT variants in PRPF8, DYRK2, and CEP78: implications for splicing and ciliogenesis

The paper identifies variants in PRPF8 and related genes associated with CAKUT, showing their role in splicing and ciliogenesis through functional experiments.

RRP7A links primary microcephaly to radial glial cells and dysfunction of ribosomal biogenesis, neurogenesis and ciliary resorption

This study identifies a mutation in RRP7A linked to primary microcephaly, showing its role in neurogenesis, ribosomal biogenesis, and ciliary resorption in neural stem cells.