Microglia mediate the early-life programming of adult glucose control
Martín Valdearcos, Emily R. McGrath, Stephen M. Brown Mayfield, Melissa G. Jacuinde, Andrew Folick, Rachel T. Cheang, Ruoyu Li, Tomás P. Bachor, Rachel N. Lippert, Allison Wanting Xu, Suneil K. Koliwad
This study shows that microglia in the mediobasal hypothalamus prune synapses during early life, influencing adult glucose control through perineuronal net refinement.
Cell Reports · Mar 1, 2025Peer-reviewedPhysiology