Martín Valdearcos

This study identifies ApoE-dependent lipid handling in median eminence microglia that preserves myelin integrity and metabolic function, showing therapeutic potential through liver X receptor activation.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

This study shows that microglia in the mediobasal hypothalamus prune synapses during early life, influencing adult glucose control through perineuronal net refinement.

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.