Suneil K. Koliwad

ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function

This study identifies ApoE-dependent lipid handling in median eminence microglia that preserves myelin integrity and metabolic function, showing therapeutic potential through liver X receptor activation.

Osteoprotegerin-Enabled Immune Evasion by Pathological Adipose Stromal Cells Drives Metabolic Dysfunction in Obesity

This study identifies senescent adipose progenitor cells (sAPCs) in obesity that produce osteoprotegerin (OPG), enabling immune evasion and metabolic dysfunction.

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Microglia mediate the early-life programming of adult glucose control

This study shows that microglia in the mediobasal hypothalamus prune synapses during early life, influencing adult glucose control through perineuronal net refinement.

Microglial inflammatory activation paradoxically improves glucose tolerance during diet-induced obesity

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.