Author

Gabriela Chrostek

Università degli Studi del Piemonte Orientale “Amedeo Avogadro”ORCID 0000-0002-5235-1561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Claudio CasaliiD· 2 shared Dmitry LimiD· 2 shared Emanuela PessolanoiD· 2 shared Giulia DematteisiD· 2 shared Justyna MaleckaiD· 2 shared Laura TapellaiD· 2 shared Marco BiggiogeraiD· 2 shared Simone ReanoiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Claudio CasaliORCID

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2 papers

Recent·Most cited

Early changes of ER-mitochondrial interaction in the liver of high-fat diet-fed mice

Justyna Malecka, Gabriela Chrostek, Claudio Casali, Emanuela Pessolano, Elena Mantovani, Nausicaa Clemente, Simone Reano, Giulia Pinton, Marco Biggiogera, Laura Tapella, Fausto Chiazza, Giulia Dematteis, Dmitry Lim

This study examines early changes in ER-mitochondrial interactions in the liver of high-fat diet-fed mice, finding reduced IP3R-Grp75-VDAC1 complex and altered MERCS structure before weight gain and glucose intolerance.

bioRxiv · Apr 14, 2026 · PreprintCell Biology

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.

Giulia Dematteis, Laura Tapella, Claudio Casali, Maria Talmon, Elisa Tonelli, Simone Reano, Adele Ariotti, Emanuela Pessolano, Justyna Malecka, Gabriela Chrostek, Gabrielė Kulkovienė, Danielius Umbrasas, Carla Distasi, Mariagrazia Grilli, Graham Ladds, , Dmitry Lim

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.

Communications Biology · Oct 10, 2024Peer-reviewedCell Biology