Claudio Casali

Breast cancer extracellular vesicles transfer P2X7 signaling competence to endothelial cells and dynamically remodel vascular migration

This study shows breast cancer-derived extracellular vesicles transfer P2X7 signaling competence to endothelial cells, enhancing anti-migratory and anti-tubulogenic effects through P2X7 sensitization.

Disruption of endothelial stability directly impacts vascular neighboring cells in Hereditary Hemorrhagic Telangiectasia

This study uses scRNA-seq and spatial transcriptomics to identify distinct endothelial cell populations in HHT biopsies and their interactions with neighboring cells.

Early changes of ER-mitochondrial interaction in the liver of high-fat diet-fed mice

This study examines early changes in ER-mitochondrial interactions in the liver of high-fat diet-fed mice, finding reduced IP3R-Grp75-VDAC1 complex and altered MERCS structure before weight gain and glucose intolerance.

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.