ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma
Mehri Monavarian, Keene Lee, Alistaire Rugerio Sherman, Imran Mohammad, Sainiteesh Maddineni, Mao Zhang, Joseph C. Wu, Katrin F. Chua, John B. Sunwoo, Andrey Finegersh
This study identifies ACTL6A as a regulator of hypoxic adaptation and metabolic plasticity in head and neck squamous cell carcinoma by modulating AP-1 signaling and chromatin structure.
bioRxiv · Sep 2, 2025 · PreprintCancer Biology