Clonally heritable gene expression imparts a layer of diversity within cell types
Jeff Eron Mold, Martin H. Weissman, Michael Ratz, Michael Hagemann-Jensen, Joanna Hård, Carl‐Johan Eriksson, Hosein Toosi, Joseph Berghenstråhle, Christoph Ziegenhain, Leonie von Berlin, Marcel Martin, Kim G. Blom, Jens Lagergren, Joakim Lundeberg, Rickard Sandberg, , Jonas Frisén
The paper identifies heritable transcriptional diversity within cell types by studying clonal human lymphocytes and mouse brain cells, showing clone-specific chromatin accessibility leads to distinct gene expression.
Cell Systems · Feb 1, 2024Peer-reviewedSystems Biology