Author

Rui Guo

The University of Texas Southwestern Medical CenterORCID 0000-0002-5294-923XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rui Guo11 papers · Fujian Agriculture and Forestry University

Biology Disciplines

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Bioinformatics· 3

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:large language model· 1

Frequent Co-Authors

Jimin PeiiD· 2 shared Qian CongiD· 2 shared Aaron L. FelleriD· 1 shared Abel GurungiD· 1 shared Adam KlieiD· 1 shared Ajasja LjubetičiD· 1 shared Akshay ChennaiD· 1 shared Alberto Perez· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioinformatics

Jimin PeiORCID

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Author profile →

3 papers

Recent·Most cited

Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Clayton W. Kosonocky, Alex M. Abel, Aaron L. Feller, Amanda Cifuentes Rieffer, Phillip R. Woolley, Jakub Lála, Delbert S. Barth, Tynan Gardner, Bits to Binders Competitors, Daniel Acosta, Stefano Angioletti‐Uberti, Vinayak Annapure, Neil Anthony, Rana A Barghout, Max Beining, , Rohit Satija

The paper validates and analyzes 12,000 AI-designed CAR-T binders from a global competition, identifying successful designs and factors improving their performance.

Molecular Systems Biology · Oct 8, 2026Peer-reviewedBioinformatics

Domain classification of archaeal proteomes reveals conserved fold repertoire

Richard Dustin Schaeffer, Jimin Pei, Rui Guo, Jing Zhang, Kirill E. Medvedev, Qian Cong, Nick V. Grishin

The paper classifies archaeal proteomes at the domain level, revealing that structural diversity is conserved across archaea and that unclassified proteins are due to classification limitations, not structural novelty.

PLoS Computational Biology · Sep 18, 2026Peer-reviewedBioinformatics

GAME: Genomic API for Model Evaluation

Ishika Luthra, Satyam Priyadarshi, Rui Guo, Lukas Mahieu, Niklas Kempynck, Damion Dooley, Dmitry Penzar, Ilya E. Vorontsov, Yilun Sheng, Xinming Tu, Adam Klie, Shiron Drusinsky, Alexander Floren, Ethan J. Armand, Kaur Alasoo, , Carl G. de Boer

GAME provides a standardized framework for benchmarking genomics models across tasks, enabling consistent evaluation and community contributions.

bioRxiv · Jul 4, 2025 · PreprintBioinformatics