Finn J Hawkins

This study develops an iPSC-based platform to functionally analyze genetic variants in lung disease, demonstrating its application in diagnosing a variant of uncertain significance in primary ciliary dyskinesia.

This study demonstrates that targeted pre-conditioning and bronchoscopic cell delivery can effectively regenerate airway epithelium in mice, with transplanted cells differentiating into functional lineages.

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

The paper identifies the Foxa2 lineage's role in lung development and demonstrates that conditional complementation of this lineage can generate a whole lung in mice.

This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.

This paper develops a method to simultaneously differentiate cardiac and lung epithelial lineages from human pluripotent stem cells to study cardio-pulmonary interactions during embryogenesis.

This paper reports the derivation of airway basal stem cells from human iPSCs, demonstrating their ability to self-renew and differentiate into airway epithelial cell types, and model lung diseases.

This study uses human stem cell-derived alveolar type 2 cells to model SARS-CoV-2 infection, revealing rapid inflammatory responses and drug efficacy against the virus.

Human iPSC-derived alveolar type II-like and airway epithelial cells adapted to two-dimensional air-liquid interface culture express ACE2 and TMPRSS2 at frequencies comparable to primary lung epithelial controls.