Author

Tianyu Cao

Johns Hopkins UniversityORCID 0000-0002-5299-847XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tianyu Cao1 paper · Shanghai Jiao Tong University

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Philip C. WongiD· 2 shared Aaron Z. WageniD· 1 shared Aine Fairbrother-BrowneiD· 1 shared Amy R. HicksiD· 1 shared Aswathy Peethambaran MallikaiD· 1 shared Benjamin J. O’CallaghaniD· 1 shared Bo Pang· 1 shared Christina E. ToomeyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Philip C. WongORCID

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2 papers

Recent·Most cited

TDP-43 loss of function drives aberrant splicing in Parkinson's disease

Jonathan Brenton, Jordan Follett, Raja Sekhar Nirujogi, Christina E. Toomey, Patricia Lopez-Garcia, James R. Evans, Yeon J. Lee, Khaja Mohieddin Syed, Guillermo Rocamora Perez, Aine Fairbrother-Browne, Karishma D’Sa, Melissa Grant‐Peters, Joanne Lachica, Amy R. Hicks, Aaron Z. Wagen, , Mina Ryten

The paper identifies splicing dysregulation in Parkinson's disease linked to TDP-43 loss of function and shows its association with genetic mutations and cellular models.

bioRxiv · Sep 4, 2025 · PreprintNeuroscience

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits

Tianyu Cao, Rashmi Thapa, Rongsong Liu, Aswathy Peethambaran Mallika, Meghraj Singh Baghel, Yijun Wei, Irika R. Sinha, Grace D. Burns, Xinrui Wen, Bo Pang, Jonathan P. Ling, Da‐Ting Lin, Yun Li, Philip C. Wong

This study uses a BBB-permeable AAV to deliver CTR and restore TDP-43 function in a mouse model of FTLD-TDP, reducing deficits and neuron loss.

bioRxiv · Aug 28, 2025 · PreprintNeuroscience