Hartmut Jaeschke

This study compares the protective effects of NAC and Fomepizole against APAP-induced liver and kidney injury in female mice, showing Fomepizole provides broader protection.

This study shows that acetaminophen-induced acute kidney injury occurs through CYP-independent mechanisms, even when hepatic CYP2E1 is deleted, highlighting the need for kidney-specific therapies.

This study shows that activating the Adenosine A2B Receptor after acetaminophen overdose accelerates liver recovery by enhancing lipid metabolism and immune responses.

This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.