Author

Tristan Félix

InsermORCID 0000-0002-5331-3153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alexandra TachtsidiiD· 1 shared Annarita MiccioiD· 1 shared Anne ChalumeauiD· 1 shared Giulia HardouiniD· 1 shared Guillaume CorreiD· 1 shared Jeanne Martin· 1 shared Letizia FontanaiD· 1 shared Margaux MomblediD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Alexandra TachtsidiORCID

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1 paper

Recent·Most cited

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

Letizia Fontana, Pierre Martinucci, Simone Amistadi, Tristan Félix, Margaux Mombled, Alexandra Tachtsidi, Guillaume Corre, Anne Chalumeau, Giulia Hardouin, Jeanne Martin, Oriana Romano, Mario Amendola, Panagiotis Antoniou, Annarita Miccio

This study uses multiplex base editing to target BCL11A enhancers, increasing fetal hemoglobin production and reducing sickle cell disease symptoms without causing significant genomic damage.

Cell Reports Medicine · Sep 27, 2025Peer-reviewedMolecular Biology