Elevated MPS1 converts the fibrous corona into a source of chromosomal instability in colon cancer
Ana Pinto-Teixeira, André Oliveira, Gonçalo Gouveia, Ana Sousa, Jessica P Roelands, Marco Grillo, Sergi Rodríguez-Calado, Carlos Resende, Helena Xavier‐Ferreira, Mariana Osswald, Hugo Girão, Patrícia Mesquita, Raquel Almeida, Marin Barišić, Jose Carlos Machado, , Carlos Conde
This study shows that elevated MPS1 causes chromosomal instability in colon cancer by converting the fibrous corona into a source of merotelic kinetochore-microtubule attachments.
bioRxiv · Aug 21, 2026 · PreprintCell Biology