Cláudio E. Sunkel

Elevated MPS1 converts the fibrous corona into a source of chromosomal instability in colon cancer

This study shows that elevated MPS1 causes chromosomal instability in colon cancer by converting the fibrous corona into a source of merotelic kinetochore-microtubule attachments.

POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy

This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.

Proximity-based activation of AURORA A by MPS1 potentiates error correction

This study identifies a proximity-based activation mechanism where MPS1 phosphorylates AURORA A kinase to enhance error correction during mitosis.

Apical constriction induces tissue rupture in a proliferative epithelium

This study shows that rapid aPKC inactivation in Drosophila follicular epithelium causes tissue rupture through increased apical constriction, not polarity loss.

Aneuploidy Promotes Intestinal Dysplasia in Drosophila

This study shows that Drosophila intestinal stem cells tolerate aneuploidy without apoptosis, leading to tissue dysplasia through increased proliferation and lineage skewing.