Marco Grillo

SixPack-AbScan: a web server to discover cross-reactivity of antibodies across species

SixPack-AbScan is a web server that computationally screens antibodies for cross-reactivity across species using epitope conservation.

Elevated MPS1 converts the fibrous corona into a source of chromosomal instability in colon cancer

This study shows that elevated MPS1 causes chromosomal instability in colon cancer by converting the fibrous corona into a source of merotelic kinetochore-microtubule attachments.

Spatial microRNA profiling at single-cell resolution by in situ barcoded extension

The paper introduces miR-Space, a method for spatial miRNA profiling at single-cell resolution, revealing new miRNA distributions and cell-type associations in brain tissues.

Targeted sequencing of mutations via RNA-templated gap filling of oligonucleotides for single-cell RNA-seq

This paper introduces a method for targeted sequencing of expressed mutations in single cells using RNA-templated gap filling with BstFL polymerase, enabling simultaneous transcriptomic and mutation profiling.

A dual genetic constraint underlies the conservation of early brains in vertebrates.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

Optimizing Xenium In Situ data utility by quality assessment and best practice analysis workflows

This study evaluates the Xenium In Situ spatial transcriptomics platform using mouse brain and human breast cancer datasets, comparing it to other technologies and benchmarking analysis tools.

Evolutionary convergence of sensory circuits in the pallium of amniotes

This study compares the development and evolution of sensory circuits in the pallium of birds, lizards, and mammals, revealing divergent developmental trajectories but functional similarity in sensory processing.

Open-source, high-throughput targeted in-situ transcriptomics for developmental biologists

The paper introduces an open-source method for high-throughput in-situ transcriptomics and provides a computational workflow for data analysis.

BirthSeq, a new method to isolate and analyze dated cells from any tissue in vertebrates

BirthSeq isolates and analyzes cells based on their birth date across vertebrate tissues, enabling temporal studies of cell fate in development.

CeLaVi: An Interactive Cell Lineage Visualisation Tool

CeLaVi is a web-based tool for visualizing and interacting with cell lineages, integrating spatial distribution and cell properties.

Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

This study uses simulations to evaluate the accuracy of CRISPR-based lineage reconstruction under various biological and technical conditions.

The genome of the crustacean Parhyale hawaiensis: a model for animal development, regeneration, immunity and lignocellulose digestion

The paper sequences and annotates the genome of Parhyale hawaiensis, identifying key genes for development, immunity, and lignocellulose digestion, providing a resource for comparative studies.