Author

Jessica Neville Little

University of VirginiaORCID 0000-0002-5343-6903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Noelle D. DwyeriD· 3 shared Katrina C. McNeelyiD· 2 shared Christopher J. BottiD· 1 shared Kaela S. LettieriiD· 1 shared Madison R. Hecht· 1 shared Nadine MicheliD· 1 shared Sara A. Martin· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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3 shared papersDevelopmental Biology

Noelle D. DwyerORCID

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3 papers

Recent·Most cited

Developmental BiologyJournal of NeurosciencePeer-reviewedFeb 23, 2021

Loss of coiled-coil protein Cep55 impairs abscission processes and results in p53-dependent apoptosis in developing cortex

Jessica Neville Little, Katrina C. McNeely, Nadine Michel…·Noelle D. Dwyer

This study shows that Cep55 loss in mice causes microcephaly through abscission defects and p53-dependent apoptosis in the developing cortex.

26 citations

mouseexperimental assay

Developmental BiologyProceedings of the National Academy of SciencesPeer-reviewedApr 9, 2020

Cytokinesis and post-abscission midbody remnants are regulated during mammalian brain development

Katrina C. McNeely, Jessica Neville Little, Noelle D. Dwyer

The paper analyzes cytokinetic furrow ingression and abscission in mouse neuroepithelium, finding developmentally regulated abscission timing and midbody release affecting daughter cell fate.

29 citations

Cell BiologyHuman Molecular GeneticsPeer-reviewedOct 4, 2018

p53 Deletion Rescues Lethal Microcephaly in a Mouse Model with Neural Stem Cell Abscission Defects

Jessica Neville Little, Noelle D. Dwyer

This study shows that p53 deletion rescues lethal microcephaly in Kif20b mutants by reducing NSC apoptosis, but not midbody maturation defects.

39 citations