Noelle D. Dwyer

Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia

This study investigates the role of Togaram1 in mammalian forebrain development using a mouse knockout, finding it crucial for forebrain size, morphology, and NSC primary cilia function.

Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia

This study examines how abscission failures in a polarized epithelium affect apical membrane size and cilia, using Cep55 knockout mouse neuroepithelium as a model.

Context-dependent inversion of the response in a single sensory neuron type reverses olfactory preference behavior

Loss of coiled-coil protein Cep55 impairs abscission processes and results in p53-dependent apoptosis in developing cortex

This study shows that Cep55 loss in mice causes microcephaly through abscission defects and p53-dependent apoptosis in the developing cortex.

Cytokinesis and post-abscission midbody remnants are regulated during mammalian brain development

The paper analyzes cytokinetic furrow ingression and abscission in mouse neuroepithelium, finding developmentally regulated abscission timing and midbody release affecting daughter cell fate.

p53 Deletion Rescues Lethal Microcephaly in a Mouse Model with Neural Stem Cell Abscission Defects

This study shows that p53 deletion rescues lethal microcephaly in Kif20b mutants by reducing NSC apoptosis, but not midbody maturation defects.