Cancer BiologyNature CommunicationsPeer-reviewed
A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells…·Neil Vasan
This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.
7 citationstop 2%