Author

Prashath Karunaraj

Columbia University Irving Medical CenterORCID 0000-0003-2719-0345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Abiha KazmiiD· 1 shared Anum Azam GlasgowiD· 1 shared Cathie M. PflegeriD· 1 shared E. Premkumar ReddyiD· 1 shared Emily Cao· 1 shared Harnoor Singh· 1 shared Ipek Simay GokuluiD· 1 shared Jing LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abiha KazmiORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMar 3, 2026

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells…·Neil Vasan

This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.

7 citationstop 2%

humanproteomics

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Developmental BiologybioRxivPreprintFeb 3, 2025

A Drosophila model for Costello Syndrome caused by Ras mutation K117R

Prashath Karunaraj, Emily Cao, Harnoor Singh…·Cathie M. Pfleger

This paper characterizes the Drosophila model of Costello Syndrome caused by the rare HRas K117R mutation, showing increased lethality, reduced body size, and specific phenotypes that suggest distinct roles for Raf-ERK and PI3K signaling pathways.

1 citation

Drosophilaexperimental assay

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