The paper shows that the endosperm supplies cell-wall-loosening proteins to the maternal seed coat, enabling maternal cell elongation and seed growth through a regulated secretory program.

bioRxiv · Oct 29, 2026 · PreprintPlant Biology

Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers

Yiheng Huang, Elizabeth C. McCulla, Jihan Park, Annabel Yang, Timothy Jho, Angelica Lin, Jie Xu, Kari Wilder-Romans, Luke D. Hess, Jing Li, Ningning Liang, Ziqing Zhu, Deven Kothari, Karen Jin, Sarah H. Kim, , Weihua Zhou

This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek Simay Gokulu, Sophia Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Peter V. Hornbeck, Jing Li, Anum Azam Glasgow, Neil Vasan

This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.

Nature Communications · Mar 3, 2026Peer-reviewedCancer Biology

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

Huiqi Fu, Jiaqi Zhong, Jiayi Zhao, Li Huo, Chong Wang, Dexuan Ma, Wenjing Pan, Limin Sun, Ziming Ren, Tianyi Fan, Ze Wang, Wenyi Wang, X. Lei, Guanghui Yu, Jing Li, , Bing Liu

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

New Phytologist · Jul 22, 2024Peer-reviewedPlant Biology

PlantC2U: Deep learning of cross-species sequence landscapes predicts plastid C-to-U RNA editing in plants

Chaoqun Xu, Jing Li, Lingyu Song, Ze‐Jun Guo, Shi‐Wei Song, Lu-Dan Zhang, Hai‐Lei Zheng

PlantC2U predicts plastid C-to-U RNA editing in plants using deep learning, achieving high accuracy and identifying tissue-specific editing patterns and stress responses.

Journal of Experimental Botany · Jan 8, 2024Peer-reviewedBioinformatics

Dual functions of ZmGI1 in the photoperiodic flowering pathway and salt stress responses in maize

Fengkai Wu, Ling Liu, Yan Kang, Jing Li, Zhiyu Ma, Baba Salifu Yahaya, Jie Xu, Qingjun Wang, Xuanjun Feng, Jingwei Li, Erliang Hu, Yaxi Liu, Yanli Lu

This study identifies ZmGI1 as a pleotropic gene in maize that regulates flowering time and confers salt stress tolerance through circadian rhythms and redox pathways.

bioRxiv · May 12, 2021 · PreprintDevelopmental Biology

The SEQC2 Epigenomics Quality Control (EpiQC) Study: Comprehensive Characterization of Epigenetic Methods, Reproducibility, and Quantification

Jonathan Foox, Jessica Nordlund, Claudia Lalancette, Ting Gong, Michelle R. Lacey, Samantha Lent, Bradley W. Langhorst, V. K. Chaithanya Ponnaluri, Louise Williams, Karthik Ramaswamy Padmanabhan, Raymond G. Cavalcante, Anders Lundmark, Daniel Butler, Chris Mozsary, Justin Gurvitch, , Christopher E. Mason

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.

bioRxiv · Dec 14, 2020 · PreprintGenomics

The involvement of HDAC3-mediated inhibition of microRNA cluster 17-92 in hyperoxia-mediated impairment of lung development in neonatal rats

Di Wang, Hui Hong, Xiaoxia Li, Jing Li, Zhiqun Zhang

This study investigates how HDAC3 regulates alveolarization and angiogenesis in BPD by modulating the miR-17-92 cluster and the EZH1-p65-Pgf axis.

Molecular Medicine · Nov 3, 2020Peer-reviewedMolecular Biology