Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation
Christopher Lee, Farah Tasnim, Xiaozhong Huang, Raman Sethi, Yaqi Song, Tatsuya Kozaki, Sebastiaan De Schepper, Nicholas Ang, Ivy Low, You Yi Hwang, Jinmiao Chen, Hanry Yu, Florent Ginhoux
This study shows that co-culturing iPSC-derived macrophages with hepatocytes enhances macrophage maturation and hepatocyte function through direct cell-cell contact.
bioRxiv · Aug 26, 2025Immunology