Author

Stuart G. Tangye

Garvan Institute of Medical ResearchORCID 0000-0002-5360-5180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Alana L. WhitcombeiD· 1 shared Ana Esteve‐SoléiD· 1 shared Andrés Augusto AriasiD· 1 shared Andrés BaenaiD· 1 shared Andrew C. SteeriD· 1 shared Aniss RafikiD· 1 shared Anne PueliD· 1 shared Anthony LauiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperImmunology

Alana L. WhitcombeORCID

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3 papers

Recent·Most cited

GeneticsThe Journal of Experimental MedicinePeer-reviewedJul 9, 2026

✦ In-depth digest

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín-Calderón, Laura E. Kilpatrick, Clément Conil…·Stéphanie Boisson‐Dupuis

Homozygosity for hypomorphic IL23R variants (G149R, G300V, R381Q) partly impairs IL-23-dependent IFN-γ production in patient cells; with L372F (effect inferred), they are enriched in tuberculosis, not MSMD or CMC patients.

1 citation

humanwhole-exome sequencing

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ImmunologyImmunityPeer-reviewedMar 1, 2026

Antibody responses against bacterial glycans affinity mature and diversify in germinal centers.

Holly A. Fryer, Catherine Pitt, Hannah R. C. Frost…·Danika Lea Hill

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.

4 citationstop 2%

humanCITE-seq

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ImmunologyImmunology and Cell BiologyPeer-reviewedSep 14, 2025

Both T and B cells contribute to dysregulated activation and differentiation of CD4+ T cells in Activated PI3K delta syndrome 1

Julia Bier, Anthony Lau, Katherine Jackson…·Elissa K. Deenick

This study investigates the role of PI3K GOF in APDS1, showing that T and B cells contribute to dysregulated T cell activation and differentiation through extrinsic mechanisms.

1 citation

mouseexperimental assay

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