Both T and B cells contribute to dysregulated activation and differentiation of CD4+ T cells in Activated PI3K delta syndrome 1
Julia Bier, Anthony Lau, Katherine Jackson, Stephanie Ruiz‐Diaz, Timothy J. Peters, Robert Adrian Brink, Stuart G. Tangye, Elissa K. Deenick
This study investigates the role of PI3K GOF in APDS1, showing that T and B cells contribute to dysregulated T cell activation and differentiation through extrinsic mechanisms.
Immunology and Cell Biology · Sep 14, 2025Peer-reviewedImmunology